| Entry |
|
|---|
| Name |
Diclofenac (USAN/INN);
Solaraze (TN);
Zorvolex (TN) |
|---|
| Formula |
C14H11Cl2NO2
|
|---|
| Exact mass |
295.0167
|
|---|
| Mol weight |
296.14
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01898 Anti-inflammatory drug, phenylacetic acid derivatives
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
Transporter inhibitor
DG02866 SLC22A8 inhibitor
|
|---|
| Remark |
| Product (DG00441): | D00903<US> D00904<JP/US> D07818<US> |
|
|---|
| Efficacy |
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
|---|
| Interaction |
Transporter inhibition: SLC22A8 [HSA: 9376]
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D11 OTHER DERMATOLOGICAL PREPARATIONS
D11A OTHER DERMATOLOGICAL PREPARATIONS
D11AX Other dermatologicals
D11AX18 Diclofenac
D07816 Diclofenac (USAN/INN)
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AB Acetic acid derivatives and related substances
M01AB05 Diclofenac
D07816 Diclofenac (USAN/INN)
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA15 Diclofenac
D07816 Diclofenac (USAN/INN)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BC Antiinflammatory agents, non-steroids
S01BC03 Diclofenac
D07816 Diclofenac (USAN/INN)
USP drug classification [BR:br08302]
Analgesics
Nonsteroidal Anti-inflammatory Drugs
Diclofenac
D07816 Diclofenac (USAN/INN)
Ophthalmic Agents
Ophthalmic Anti-inflammatories
Nonsteroidal Anti-Inflammatory Drugs, Ophthalmic
Diclofenac
D07816 Diclofenac (USAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Diclofenac
D07816 Diclofenac (USAN/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01898 Anti-inflammatory drug, phenylacetic acid derivatives
DG00441 Diclofenac
D07816 Diclofenac
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00441 Diclofenac
D07816 Diclofenac
Transporter inhibitor
DG02866 SLC22A8 inhibitor
DG00441 Diclofenac
D07816 Diclofenac
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D07816 Diclofenac (USAN/INN)
PTGS2 (COX2)
D07816 Diclofenac (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07816
Drug transporters
D07816
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01898 Anti-inflammatory drug, phenylacetic acid derivatives
DG00441 Diclofenac
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00441 Diclofenac
Transporter inhibitor
DG02866 SLC22A8 inhibitor
DG00441 Diclofenac
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 19
1 C8x C 22.4000 -19.3200
2 C8x C 22.4000 -20.7200
3 C8x C 23.5900 -21.4200
4 C8x C 24.7800 -20.7200
5 C8y C 24.7800 -19.3200
6 C8y C 23.5900 -18.6200
7 C1b C 26.0400 -18.6200
8 C6a C 27.2300 -19.2500
9 O6a O 28.4200 -18.6200
10 O6a O 27.2300 -20.7200
11 N1b N 23.5900 -17.2200
12 C8y C 22.3300 -16.5200
13 C8y C 22.3300 -15.1200
14 C8x C 21.1400 -14.4200
15 C8x C 19.9500 -15.1200
16 C8x C 19.9500 -16.5200
17 C8y C 21.1400 -17.2200
18 X Cl 23.5900 -14.4200
19 X Cl 21.1400 -18.6200
BOND 20
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 1
10 8 10 2
11 6 11 1
12 11 12 1
13 12 13 2
14 13 14 1
15 14 15 2
16 15 16 1
17 16 17 2
18 12 17 1
19 13 18 1
20 17 19 1
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