KEGG   DRUG: Revumenib citrate
Entry
D12729                      Drug                                   
Name
Revumenib citrate (USAN);
Revumenib monocitrate monohydrate;
Revuforj (TN)
Product
REVUFORJ (Syndax Pharmaceuticals)
Formula
C32H47FN6O4S. C6H8O7. H2O
Exact mass
840.3739
Mol weight
840.96
Structure
Remark
Chemical structure group: DG03279
Product (DG03279): D12729<US>
Efficacy
Antineoplastic, Menin-MLL interaction inhibitor
  Disease
Acute leukemia (with a KMT2A translocation) [DS:H00003 H00001 H00002]
Target
MEN1 [HSA:4221] [KO:K14970]
  Pathway
hsa05202  Transcriptional misregulation in cancer
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Cellular process
   Chromatin
    MEN1
     D12729  Revumenib citrate (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12729
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12729
Other DBs
CAS: 2761046-45-9
PubChem: 497621142
LinkDB
KCF data

ATOM        58
            1   C8y C    23.6623  -14.2393
            2   C8y C    22.4757  -13.5413
            3   N1y N    21.2891  -14.2393
            4   C1z C    19.3347  -14.2393
            5   C1x C    20.3119  -13.2621
            6   C1x C    20.3119  -15.2165
            7   C1x C    17.2407  -15.4259
            8   N1y N    16.5427  -14.2393
            9   C1x C    17.2407  -13.0527
            10  C1x C    18.6367  -13.0527
            11  C1x C    18.6367  -15.4259
            12  C1b C    15.1467  -14.2393
            13  C1y C    14.4487  -15.4259
            14  C1x C    15.1467  -16.6823
            15  C1x C    14.4487  -17.9387
            16  C1y C    12.9829  -17.9387
            17  C1x C    12.2849  -16.7521
            18  C1x C    12.9829  -15.4259
            19  N1b N    12.2849  -19.1253
            20  S4a S    10.8889  -19.1253
            21  C1b C     9.4929  -19.1253
            22  C1a C     8.7950  -20.3119
            23  O3c O    10.8889  -17.7293
            24  O3c O    10.8889  -20.5213
            25  N5x N    22.4757  -12.1453
            26  C8x C    23.6623  -11.4473
            27  N5x N    24.9187  -12.1453
            28  C8x C    24.9187  -13.5413
            29  C8y C    27.2919  -17.7991
            30  C8x C    27.2919  -16.4031
            31  C8x C    26.1053  -15.6353
            32  C8y C    24.8489  -16.4031
            33  C8y C    24.8489  -17.7991
            34  C8x C    26.1053  -18.4971
            35  C5a C    23.6623  -18.4971
            36  N1c N    22.4757  -17.7991
            37  C1c C    21.2891  -18.4971
            38  O5a O    23.6623  -19.8931
            39  C1a C    20.1025  -17.7991
            40  C1b C    22.4757  -16.4031
            41  C1a C    21.2891  -19.8931
            42  C1a C    21.2891  -15.6353
            43  O2a O    23.6623  -15.6353
            44  X   F    28.4784  -18.4971
            45  C1d C    34.0953  -17.0132
            46  C1b C    32.9751  -17.7134
            47  C1b C    35.2856  -17.7134
            48  C6a C    34.7955  -15.8930
            49  O1a O    33.3952  -15.8930
            50  C6a C    31.7849  -17.0832
            51  C6a C    35.2856  -19.1136
            52  O6a O    34.0953  -14.7027
            53  O6a O    36.3358  -15.8930
            54  O6a O    30.5246  -17.7834
            55  O6a O    31.7849  -15.7530
            56  O6a O    36.6859  -19.8838
            57  O6a O    34.0953  -19.8838
            58  O0  O    31.1500  -12.6000
BOND        60
            1     2   3 1
            2     4   5 1
            3     5   3 1
            4     3   6 1
            5     4   6 1
            6     7   8 1
            7     8   9 1
            8     9  10 1
            9    10   4 1
            10    4  11 1
            11    7  11 1
            12    8  12 1
            13   13  12 1 #Down
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   13  18 1
            20   16  19 1 #Up
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   20  23 2
            25   20  24 2
            26    1   2 1
            27    2  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   28   1 2
            32   29  30 2
            33   30  31 1
            34   31  32 2
            35   32  33 1
            36   33  34 2
            37   29  34 1
            38   33  35 1
            39   35  36 1
            40   36  37 1
            41   35  38 2
            42   37  39 1
            43   36  40 1
            44   37  41 1
            45   40  42 1
            46   32  43 1
            47   29  44 1
            48   43   1 1
            49   45  46 1
            50   45  47 1
            51   45  48 1
            52   45  49 1
            53   46  50 1
            54   47  51 1
            55   48  52 1
            56   48  53 2
            57   50  54 1
            58   50  55 2
            59   51  56 1
            60   51  57 2

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