Homo sapiens (human): 4221 Help Entry 4221              CDS       T01001                                  Symbol MEN1, MEAI, SCG2 Name (RefSeq) menin 1   KO K14970   menin Organism hsa  Homo sapiens (human) Pathway hsa04934   Cushing syndrome hsa05202   Transcriptional misregulation in cancer Network nt06360  Cushing syndrome   Element N00290   Mutation-inactivated MEN1 to transcription Disease H00033   Adrenal carcinoma H00034   Carcinoid H00045   Pancreatic neuroendocrine tumor H00246   Primary hyperparathyroidism H00247   Multiple endocrine neoplasia syndrome H01102   Pituitary adenomas H01431   Cushing syndrome H01522   Zollinger-Ellison syndrome H01667   Medulloblastoma H02049   Bilateral macronodular adrenal hyperplasia Drug target Icovamenib:  D12727 Revumenib (DG03279):  D12728 D12729<US> Ziftomenib:  D12419 Brite KEGG Orthology (KO) [BR:hsa00001]  09160 Human Diseases   09161 Cancer: overview    05202 Transcriptional misregulation in cancer     4221 (MEN1)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     4221 (MEN1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     4221 (MEN1) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HMT complexes     MLL-HCF complex      4221 (MEN1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Menin Motif Other DBs NCBI-GeneID:  4221 NCBI-ProteinID:  NP_570711 OMIM:  613733 HGNC:  7010 Ensembl:  ENSG00000133895 UniProt:  O00255 Structure PDBPDBj LinkDB All DBs Position 11:complement(64803516..64811294) Genome browser AA seq 610 aa AA seqDB search MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK VSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSED HAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMV CAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLT LYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEI YKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGI CKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRR RGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAP TASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTL SFLKRQRKGL NT seq 1833 nt NT seq  +upstreamnt  +downstreamnt atggggctgaaggccgcccagaagacgctgttcccgctgcgctccatcgacgacgtggtg cgcctgtttgctgccgagctgggccgagaggagccggacctggtgctcctttccttggtg ctgggcttcgtggagcattttctggctgtcaaccgcgtcatccctaccaacgttcccgag ctcaccttccagcccagccccgcccccgacccgcctggcggcctcacctactttcccgtg gccgacctgtctatcatcgccgccctctatgcccgcttcaccgcccagatccgaggcgcc gtcgacctgtccctctatcctcgagaagggggtgtctccagccgtgagctggtgaagaag gtctccgatgtcatatggaacagcctcagccgctcctacttcaaggatcgggcccacatc cagtccctcttcagcttcatcacaggcaccaaattggacagctccggtgtggcctttgct gtggttggggcctgccaggccctgggtctccgggatgtccacctcgccctgtctgaggat catgcctgggtagtgtttgggcccaatggggagcagacagctgaggtcacctggcacggc aagggcaacgaggaccgcaggggccagacagtcaatgccggtgtggctgagcggagctgg ctgtacctgaaaggatcatacatgcgctgtgaccgcaagatggaggtggcgttcatggtg tgtgccatcaacccttccattgacctgcacaccgactcgctggagcttctgcagctgcag cagaagctgctctggctgctctatgacctgggacatctggaaaggtaccccatggcctta gggaacctggcagatctagaggagctggagcccacccctggccggccagacccactcacc ctctaccacaagggcattgcctcagccaagacctactatcgggatgaacacatctacccc tacatgtacctggctggctaccactgtcgcaaccgcaatgtgcgggaagccctgcaggcc tgggcggacacggccactgtcatccaggactacaactactgccgggaagacgaggagatc tacaaggagttctttgaagtagccaatgatgtcatccccaacctgctgaaggaggcagcc agcttgctggaggcgggcgaggagcggccgggggagcaaagccagggcacccagagccaa ggttccgccctccaggaccctgagtgcttcgcccacctgctgcgattctacgacggcatc tgcaaatgggaggagggcagtcccacgcctgtgctgcatgtgggctgggccacctttctt gtgcagtccctaggccgttttgagggacaggtgcggcagaaggtgcgcatagtgagccga gaggccgaggcggccgaggccgaggagccgtggggcgaggaagcccgggaaggccggcgg cggggcccacggcgggagtccaagccagaggagcccccgccgcccaagaagccagcactg gacaagggcctgggcaccggccagggtgcagtgtcaggacccccccggaagcctcctggg actgtcgctggcacagcccgaggccctgaaggtggcagcacggctcaggtgccagcaccc acagcatcaccaccgccggagggtccagtgctcactttccagagtgagaagatgaagggc atgaaggagctgctggtggccaccaagatcaactcgagcgccatcaagctgcaactcacg gcacagtcgcaagtgcagatgaagaagcagaaagtgtccacccctagtgactacactctg tctttcctcaagcggcagcgcaaaggcctctga

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