BG101934A - Имидазо(1,2-а)пиридинови производни - Google Patents

Имидазо(1,2-а)пиридинови производни

Info

Publication number
BG101934A
BG101934A BG101934A BG10193497A BG101934A BG 101934 A BG101934 A BG 101934A BG 101934 A BG101934 A BG 101934A BG 10193497 A BG10193497 A BG 10193497A BG 101934 A BG101934 A BG 101934A
Authority
BG
Bulgaria
Prior art keywords
alkyl
imidazo
pyridine derivatives
halogen
formulawhere
Prior art date
Application number
BG101934A
Other languages
English (en)
Inventor
Paul Beswick
Ian Campbell
Alan Naylor
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9506965.4A external-priority patent/GB9506965D0/en
Priority claimed from GBGB9512099.4A external-priority patent/GB9512099D0/en
Priority claimed from GBGB9516117.0A external-priority patent/GB9516117D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of BG101934A publication Critical patent/BG101934A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Съединенията са силни и избирателни инхибитори наСОХ-2 и се използват за лечение на болки, температура, възпаления при различни състояния и заболявания. Съединенията и техните фармацевтично приемливи производни имат формула, в която Ro означава халоген, R1 и R2 са независимо избрани от водород, халоген, C1-4 алкил, C1-4 алкил, заместен с един илиповече флуорни атома, C1-4 алкокси, C1-4 хидроксиалкил, SC1-4 алкил, C(0)H или C(0)C1-4 алкил и R3 е C1-4 алкил.
BG101934A 1995-04-04 1997-09-30 Имидазо(1,2-а)пиридинови производни BG101934A (bg)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9506965.4A GB9506965D0 (en) 1995-04-04 1995-04-04 Chemical compounds
GBGB9512099.4A GB9512099D0 (en) 1995-06-14 1995-06-14 Chemical compounds
GBGB9516117.0A GB9516117D0 (en) 1995-08-05 1995-08-05 Chemical compounds
PCT/EP1996/001438 WO1996031509A1 (en) 1995-04-04 1996-04-02 IMIDAZO[1,2-a]PYRIDINE DERIVATIVES

Publications (1)

Publication Number Publication Date
BG101934A true BG101934A (bg) 1999-04-30

Family

ID=27267657

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101934A BG101934A (bg) 1995-04-04 1997-09-30 Имидазо(1,2-а)пиридинови производни

Country Status (17)

Country Link
EP (1) EP0819127A1 (bg)
JP (1) JPH11501049A (bg)
KR (1) KR19980703559A (bg)
CN (1) CN1186492A (bg)
AU (1) AU5276696A (bg)
BG (1) BG101934A (bg)
CA (1) CA2216809A1 (bg)
CZ (1) CZ313397A3 (bg)
EA (1) EA199700209A1 (bg)
HU (1) HUP9801602A3 (bg)
IS (1) IS4570A (bg)
NO (1) NO974595L (bg)
NZ (1) NZ304886A (bg)
PL (1) PL322623A1 (bg)
SK (1) SK133297A3 (bg)
TR (1) TR199701105T1 (bg)
WO (1) WO1996031509A1 (bg)

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US6307047B1 (en) 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6525053B1 (en) 1997-08-22 2003-02-25 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
ES2231757T3 (es) 1997-09-05 2005-05-16 Glaxo Group Limited Composiciones farmaceutica que comprenden derivados de 2,3-diaril-pirazolo (1,5-b) piridazina.
FR2770131A1 (fr) * 1997-10-27 1999-04-30 Union Pharma Scient Appl Nouvelle association pharmaceutique a activite analgesique
FR2771005B1 (fr) * 1997-11-18 2002-06-07 Union Pharma Scient Appl Nouvelle association pharmaceutique a activite analgesique
GB9810920D0 (en) * 1998-05-21 1998-07-22 Merck Sharp & Dohme Therapeutic use
ES2140354B1 (es) 1998-08-03 2000-11-01 S A L V A T Lab Sa Imidazo (1,2a) azinas sustituidas como inhibidores selectivos de la cox-2.
TW587079B (en) 1998-09-25 2004-05-11 Almirall Prodesfarma Ag 2-phenylpyran-4-one derivatives
BR9915011A (pt) * 1998-11-03 2001-08-07 Glaxo Group Ltd Compostos, método para a preparação dos mesmos, composição farmacêutica, métodos de tratamento de um indivìduo humano ou animal sofrendo de uma condição que é mediada pela inibição seletiva de cox-2 e sofrendo de um distúrbio inflamatório, e, uso de um composto
EP1157025B1 (en) 1999-02-27 2004-03-10 Glaxo Group Limited Pyrazolopyridines
GB9930358D0 (en) * 1999-12-22 2000-02-09 Glaxo Group Ltd Process for the preparation of chemical compounds
NZ519781A (en) 1999-12-23 2004-04-30 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
GB0002312D0 (en) * 2000-02-01 2000-03-22 Glaxo Group Ltd Medicaments
PE20011333A1 (es) 2000-03-16 2002-01-16 Almirall Prodesfarma Ag Derivados de 2-fenilpiran-4-ona como inhibidores de ciclooxigenasa 2
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
CA2415577C (en) 2000-07-20 2010-10-19 Lauras As Use of cox-2 inhibitors for preventing immunodeficiency
PE20020506A1 (es) * 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
GB0025449D0 (en) * 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
US6919352B2 (en) 2000-12-15 2005-07-19 Smithkline Beecham Corporation Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds
ES2243579T3 (es) 2000-12-15 2005-12-01 Glaxo Group Ltd Derivados de pirazolopirideno.
DE60201074T2 (de) 2001-03-08 2005-09-15 Smithkline Beecham Corp. Pyrazolopyridinderivate
JP4237497B2 (ja) 2001-03-30 2009-03-11 スミスクライン ビーチャム コーポレーション ピラゾロピリジン類、その調製方法及びその治療用化合物としての使用
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US6756498B2 (en) 2001-04-27 2004-06-29 Smithkline Beecham Corporation Process for the preparation of chemical compounds
WO2002088124A2 (en) 2001-04-27 2002-11-07 Smithkline Beecham Corporation Pyrazolo'1,5-a!pyridine derivatives
HUP0400266A2 (hu) 2001-06-21 2004-08-30 Smithkline Beecham Corp. Imidazo[1,2-a]piridin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk herpeszvírus-fertőzések megelőzésére vagy kezelésére
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
WO2003031446A1 (en) 2001-10-05 2003-04-17 Smithkline Beecham Corporation Imidazo-pyridine derivatives for use in the treatment of herpes viral infection
GB0124931D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124941D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124939D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124938D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124936D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124933D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124934D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
DE60222465T2 (de) 2001-12-11 2008-06-05 Smithkline Beecham Corp. Pyrazolopyridin-derivate als antiherpesmittel
DK1474395T3 (da) 2002-02-12 2008-02-11 Smithkline Beecham Corp Nicotinamidderivater, der er nyttige som p38-inhibitorer
US7211598B2 (en) 2002-06-28 2007-05-01 Nitromed, Inc. Oxime and/or hydrozone containing nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
GB0217757D0 (en) 2002-07-31 2002-09-11 Glaxo Group Ltd Novel compounds
EP1546148A1 (en) 2002-10-03 2005-06-29 SmithKline Beecham Corporation Therapeutic compounds based on pyrazolopyridine derivatives
KR20040072004A (ko) 2003-02-07 2004-08-16 삼성에스디아이 주식회사 유기 전계 발광 소자용 발광 화합물 및 그를 이용한 유기전계발광 소자
GB0308185D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0308201D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0308186D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
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GB0318814D0 (en) 2003-08-11 2003-09-10 Smithkline Beecham Corp Novel compounds
US8067464B2 (en) 2004-10-04 2011-11-29 Nitromed, Inc. Compositions and methods using apocynin compounds and nitric oxide donors
US20090018091A1 (en) 2005-08-02 2009-01-15 Nitromed, Inc. Nitric Oxide Enhancing Antimicrobial Compounds, Compositions and Methods of Use
US8067414B2 (en) 2006-03-29 2011-11-29 Nicox S.A. Nitric oxide enhancing prostaglandin compounds, compositions and methods of use
JP5357763B2 (ja) 2006-11-06 2013-12-04 トレロ ファーマシューティカルズ， インコーポレイテッド イミダゾ［１，２−ｂ］ピリダジン誘導体およびピラゾロ［１，５−ａ］ピリダジン誘導体およびプロテインキナーゼインヒビターとしてのこれらの使用
HUE052198T2 (hu) 2011-07-21 2021-04-28 Sumitomo Dainippon Pharma Oncology Inc Heterociklusos protein kináz inhibitorok
EP3292213A1 (en) 2015-05-04 2018-03-14 Academisch Medisch Centrum Biomarkers for the detection of aspirin insensitivity
MX2021009371A (es) 2019-02-12 2021-09-10 Sumitomo Pharma Oncology Inc Formulaciones que comprenden inhibidores de proteina cinasa heterociclicos.
WO2022195579A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases

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Also Published As

Publication number Publication date
SK133297A3 (en) 1998-07-08
CA2216809A1 (en) 1996-10-10
CZ313397A3 (cs) 1998-03-18
CN1186492A (zh) 1998-07-01
WO1996031509A1 (en) 1996-10-10
AU5276696A (en) 1996-10-23
MX9707379A (es) 1997-11-29
PL322623A1 (en) 1998-02-02
JPH11501049A (ja) 1999-01-26
NZ304886A (en) 1998-11-25
HUP9801602A2 (hu) 1998-11-30
EP0819127A1 (en) 1998-01-21
IS4570A (is) 1997-09-25
NO974595D0 (no) 1997-10-03
HUP9801602A3 (en) 1999-01-28
EA199700209A1 (ru) 1998-04-30
KR19980703559A (ko) 1998-11-05
NO974595L (no) 1997-12-03
TR199701105T1 (xx) 1998-02-21

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