BG101934A - Imidazo(1,2-a)pyridine derivatives - Google Patents

Imidazo(1,2-a)pyridine derivatives

Info

Publication number
BG101934A
BG101934A BG101934A BG10193497A BG101934A BG 101934 A BG101934 A BG 101934A BG 101934 A BG101934 A BG 101934A BG 10193497 A BG10193497 A BG 10193497A BG 101934 A BG101934 A BG 101934A
Authority
BG
Bulgaria
Prior art keywords
alkyl
imidazo
pyridine derivatives
halogen
formulawhere
Prior art date
Application number
BG101934A
Other languages
Bulgarian (bg)
Inventor
Paul Beswick
Ian Campbell
Alan Naylor
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9506965.4A external-priority patent/GB9506965D0/en
Priority claimed from GBGB9512099.4A external-priority patent/GB9512099D0/en
Priority claimed from GBGB9516117.0A external-priority patent/GB9516117D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of BG101934A publication Critical patent/BG101934A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The compounds are strong and selective inhibitors of COX-2and are used for treatment of pains, high temperature,inflammations in different conditions and diseases. The compoundsand their pharmacuetically acceptable derivatives have the formulawhere Ro means halogen, R1 & R2 separately are selected fromhydrogen, halogen, C1-4 alkyl, C1-4 alkyl substituted by one ormore fluorine atoms, C1-4 hydoxyalkyl, SC1-4 alkyl, C(O)H or C(O)C1-4 alkyl and R3 is C1-4 alkyl.19 claims
BG101934A 1995-04-04 1997-09-30 Imidazo(1,2-a)pyridine derivatives BG101934A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9506965.4A GB9506965D0 (en) 1995-04-04 1995-04-04 Chemical compounds
GBGB9512099.4A GB9512099D0 (en) 1995-06-14 1995-06-14 Chemical compounds
GBGB9516117.0A GB9516117D0 (en) 1995-08-05 1995-08-05 Chemical compounds
PCT/EP1996/001438 WO1996031509A1 (en) 1995-04-04 1996-04-02 IMIDAZO[1,2-a]PYRIDINE DERIVATIVES

Publications (1)

Publication Number Publication Date
BG101934A true BG101934A (en) 1999-04-30

Family

ID=27267657

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101934A BG101934A (en) 1995-04-04 1997-09-30 Imidazo(1,2-a)pyridine derivatives

Country Status (17)

Country Link
EP (1) EP0819127A1 (en)
JP (1) JPH11501049A (en)
KR (1) KR19980703559A (en)
CN (1) CN1186492A (en)
AU (1) AU5276696A (en)
BG (1) BG101934A (en)
CA (1) CA2216809A1 (en)
CZ (1) CZ313397A3 (en)
EA (1) EA199700209A1 (en)
HU (1) HUP9801602A3 (en)
IS (1) IS4570A (en)
NO (1) NO974595L (en)
NZ (1) NZ304886A (en)
PL (1) PL322623A1 (en)
SK (1) SK133297A3 (en)
TR (1) TR199701105T1 (en)
WO (1) WO1996031509A1 (en)

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US6307047B1 (en) 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
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ES2231757T3 (en) 1997-09-05 2005-05-16 Glaxo Group Limited PHARMACEUTICAL COMPOSITIONS THAT INCLUDE DERIVATIVES OF 2,3-DIARIL-PIRAZOLO (1,5-B) PIRIDAZINE.
FR2770131A1 (en) * 1997-10-27 1999-04-30 Union Pharma Scient Appl Analgesic combinations of a cyclooxygenase-2 inhibitor and acetaminophen or an opiate having synergistic activity
FR2771005B1 (en) * 1997-11-18 2002-06-07 Union Pharma Scient Appl NEW PHARMACEUTICAL ASSOCIATION WITH ANALGESIC ACTIVITY
GB9810920D0 (en) * 1998-05-21 1998-07-22 Merck Sharp & Dohme Therapeutic use
ES2140354B1 (en) 1998-08-03 2000-11-01 S A L V A T Lab Sa IMIDAZO (1,2A) AZINAS SUBSTITUTED AS SELECTIVE INHIBITORS OF COX-2.
TW587079B (en) 1998-09-25 2004-05-11 Almirall Prodesfarma Ag 2-phenylpyran-4-one derivatives
BR9915011A (en) * 1998-11-03 2001-08-07 Glaxo Group Ltd Compounds, method for preparing them, pharmaceutical composition, methods of treating a human or animal individual suffering from a condition that is mediated by selective inhibition of cox-2 and suffering from an inflammatory disorder, and, use of a compound
EP1157025B1 (en) 1999-02-27 2004-03-10 Glaxo Group Limited Pyrazolopyridines
GB9930358D0 (en) * 1999-12-22 2000-02-09 Glaxo Group Ltd Process for the preparation of chemical compounds
NZ519781A (en) 1999-12-23 2004-04-30 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
GB0002312D0 (en) * 2000-02-01 2000-03-22 Glaxo Group Ltd Medicaments
PE20011333A1 (en) 2000-03-16 2002-01-16 Almirall Prodesfarma Ag DERIVATIVES OF 2-FENYLPYRAN-4-ONA AS INHIBITORS OF CYCLOOXYGENASE 2
PE20020146A1 (en) * 2000-07-13 2002-03-31 Upjohn Co OPHTHALMIC FORMULATION INCLUDING A CYCLOOXYGENASE-2 (COX-2) INHIBITOR
CA2415577C (en) 2000-07-20 2010-10-19 Lauras As Use of cox-2 inhibitors for preventing immunodeficiency
PE20020506A1 (en) * 2000-08-22 2002-07-09 Glaxo Group Ltd PIRAZOLE DERIVATIVES FUSED AS PROTEIN KINASE INHIBITORS
GB0025449D0 (en) * 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
US6919352B2 (en) 2000-12-15 2005-07-19 Smithkline Beecham Corporation Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds
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JP4237497B2 (en) 2001-03-30 2009-03-11 スミスクライン ビーチャム コーポレーション Pyrazolopyridines, their preparation and their use as therapeutic compounds
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US6756498B2 (en) 2001-04-27 2004-06-29 Smithkline Beecham Corporation Process for the preparation of chemical compounds
WO2002088124A2 (en) 2001-04-27 2002-11-07 Smithkline Beecham Corporation Pyrazolo'1,5-a!pyridine derivatives
HUP0400266A2 (en) 2001-06-21 2004-08-30 Smithkline Beecham Corp. Pharmaceutical compositions containing imidazo[1,2-a]pyridine derivatives, and their use for the prophylaxis and treatment of herpes viral infections
AR038957A1 (en) 2001-08-15 2005-02-02 Pharmacia Corp COMBINATION THERAPY FOR CANCER TREATMENT
WO2003031446A1 (en) 2001-10-05 2003-04-17 Smithkline Beecham Corporation Imidazo-pyridine derivatives for use in the treatment of herpes viral infection
GB0124931D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124941D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124939D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124938D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124936D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124933D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124934D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
DE60222465T2 (en) 2001-12-11 2008-06-05 Smithkline Beecham Corp. PYRAZOLOPYRIDINE DERIVATIVES AS ANTI-HERPING AGENTS
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GB0217757D0 (en) 2002-07-31 2002-09-11 Glaxo Group Ltd Novel compounds
EP1546148A1 (en) 2002-10-03 2005-06-29 SmithKline Beecham Corporation Therapeutic compounds based on pyrazolopyridine derivatives
KR20040072004A (en) 2003-02-07 2004-08-16 삼성에스디아이 주식회사 Emitting compound for electroluminescence device and device using thereof
GB0308185D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0308201D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0308186D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
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HUE052198T2 (en) 2011-07-21 2021-04-28 Sumitomo Dainippon Pharma Oncology Inc Heterocyclic protein kinase inhibitors
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Also Published As

Publication number Publication date
SK133297A3 (en) 1998-07-08
CA2216809A1 (en) 1996-10-10
CZ313397A3 (en) 1998-03-18
CN1186492A (en) 1998-07-01
WO1996031509A1 (en) 1996-10-10
AU5276696A (en) 1996-10-23
MX9707379A (en) 1997-11-29
PL322623A1 (en) 1998-02-02
JPH11501049A (en) 1999-01-26
NZ304886A (en) 1998-11-25
HUP9801602A2 (en) 1998-11-30
EP0819127A1 (en) 1998-01-21
IS4570A (en) 1997-09-25
NO974595D0 (en) 1997-10-03
HUP9801602A3 (en) 1999-01-28
EA199700209A1 (en) 1998-04-30
KR19980703559A (en) 1998-11-05
NO974595L (en) 1997-12-03
TR199701105T1 (en) 1998-02-21

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