GB1107071A - Cosmetic depigmenting compositions - Google Patents
Cosmetic depigmenting compositionsInfo
- Publication number
- GB1107071A GB1107071A GB12973/65A GB1297365A GB1107071A GB 1107071 A GB1107071 A GB 1107071A GB 12973/65 A GB12973/65 A GB 12973/65A GB 1297365 A GB1297365 A GB 1297365A GB 1107071 A GB1107071 A GB 1107071A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- carbons
- alkyl
- preferred
- ethylamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 239000002537 cosmetic Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 2
- 235000006708 antioxidants Nutrition 0.000 abstract 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 abstract 2
- 239000007854 depigmenting agent Substances 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000000699 topical effect Effects 0.000 abstract 2
- DENMGZODXQRYAR-UHFFFAOYSA-N 2-(dimethylamino)ethanethiol Chemical compound CN(C)CCS DENMGZODXQRYAR-UHFFFAOYSA-N 0.000 abstract 1
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 abstract 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 150000001338 aliphatic hydrocarbons Chemical group 0.000 abstract 1
- 150000001336 alkenes Chemical class 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000006071 cream Substances 0.000 abstract 1
- 150000001924 cycloalkanes Chemical class 0.000 abstract 1
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 239000001282 iso-butane Substances 0.000 abstract 1
- 235000013847 iso-butane Nutrition 0.000 abstract 1
- 239000006210 lotion Substances 0.000 abstract 1
- 229960003151 mercaptamine Drugs 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- -1 morpholino, pyrrolidino Chemical group 0.000 abstract 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 230000019612 pigmentation Effects 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Topical compositions for reducing the pigmentation of the skin comprise a cosmetically acceptable topical carrier together with 0.1-30% by weight of a C2-C6 aliphatic hydrocarbon substituted on one carbon by an -SH or -SCOR group, wherein R is alkyl having up to 6 carbons, and on a different carbon by an -NR\svR\yF group, wherein either (i) R\sv + R\yF together with the nitrogen form part of heterocycle; or (ii) R\sv is alkyl having up to 6 carbons and R\yF is H or an alkyl group having up to 6 carbons; or (iii) providing that the active agent is present only as the acid addition salt, or the composition has a pH below 6.0 and/or contains an anti-oxidant, R\sv and R\yF may each be H or an alkyl group having up to 6 carbons. The preferred depigmenting agents are 2-mercapto-ethylamine, and N,N-dimethyl-2-mercapto-ethylamine. The aliphatic residue may be saturated or unsaturated or cyclised (e.g. from ethane, n-butane or iso-butane, or the corresponding alkenes or cyclo-alkanes). The sulphydryl group is preferably on a primary carbon atom. When R\sv and R\yF form part of a heterocycle group, such groups may be morpholino, pyrrolidino or piperidino. The compositions may take the form of hydrophilic or hydrophobic ointments, creams, or aqueous, non-aqueous or emulsified lotions, and may include active ingredients such as exfoliating agents, and other depigmenting agents (e.g. catechol). The preferred pH is 3.9 to 4.1; preferred anti-oxidants are the methyl or propyl esters of p-hydroxy-benzoic acid. The acid addition salt of the active agent may be the hydrochloride.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36245864A | 1964-04-24 | 1964-04-24 | |
| US36249564A | 1964-04-24 | 1964-04-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1107071A true GB1107071A (en) | 1968-03-20 |
Family
ID=27001680
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB42675/67A Expired GB1107072A (en) | 1964-04-24 | 1965-03-26 | Cosmetic depigmenting compositions |
| GB12973/65A Expired GB1107071A (en) | 1964-04-24 | 1965-03-26 | Cosmetic depigmenting compositions |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB42675/67A Expired GB1107072A (en) | 1964-04-24 | 1965-03-26 | Cosmetic depigmenting compositions |
Country Status (9)
| Country | Link |
|---|---|
| BE (1) | BE662891A (en) |
| BR (1) | BR6569145D0 (en) |
| CH (1) | CH499318A (en) |
| DE (1) | DE1492171A1 (en) |
| DK (1) | DK111212B (en) |
| ES (1) | ES312173A1 (en) |
| GB (2) | GB1107072A (en) |
| NL (1) | NL6505119A (en) |
| OA (1) | OA01702A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2177917A (en) * | 1985-07-09 | 1987-02-04 | Aws Shakir Mustafa Salim | Dermatologically active substances |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH566780A5 (en) * | 1970-06-24 | 1975-09-30 | Bristol Myers Co | |
| US4136166A (en) * | 1977-04-18 | 1979-01-23 | Helena Rubinstein, Inc. | Skin lightening composition |
| FR2608425B1 (en) * | 1986-12-17 | 1989-04-28 | Rofsa Cerd | COSMETIC COMPOSITION FOR PARTIAL SELECTIVE DEPIGMENTATION OF THE SKIN AND METHOD FOR THE PRODUCTION THEREOF |
-
1965
- 1965-03-26 GB GB42675/67A patent/GB1107072A/en not_active Expired
- 1965-03-26 GB GB12973/65A patent/GB1107071A/en not_active Expired
- 1965-04-12 CH CH518865A patent/CH499318A/en not_active IP Right Cessation
- 1965-04-20 OA OA51654A patent/OA01702A/en unknown
- 1965-04-22 BE BE662891D patent/BE662891A/xx unknown
- 1965-04-22 NL NL6505119A patent/NL6505119A/xx unknown
- 1965-04-23 DE DE19651492171 patent/DE1492171A1/en active Pending
- 1965-04-23 BR BR169145/65A patent/BR6569145D0/en unknown
- 1965-04-23 ES ES0312173A patent/ES312173A1/en not_active Expired
-
1966
- 1966-07-29 DK DK395666AA patent/DK111212B/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2177917A (en) * | 1985-07-09 | 1987-02-04 | Aws Shakir Mustafa Salim | Dermatologically active substances |
| GB2177917B (en) * | 1985-07-09 | 1990-01-17 | Aws Shakir Mustafa Salim | Dermatologically active substances |
Also Published As
| Publication number | Publication date |
|---|---|
| GB1107072A (en) | 1968-03-20 |
| OA01702A (en) | 1969-12-15 |
| ES312173A1 (en) | 1966-03-16 |
| DK111212B (en) | 1968-07-01 |
| DE1492171A1 (en) | 1970-01-15 |
| BR6569145D0 (en) | 1973-09-06 |
| NL6505119A (en) | 1965-10-25 |
| CH499318A (en) | 1970-11-30 |
| BE662891A (en) | 1965-10-22 |
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