IE822105L - Benzo heterocycles - Google Patents

Benzo heterocycles

Info

Publication number
IE822105L
IE822105L IE822105A IE210582A IE822105L IE 822105 L IE822105 L IE 822105L IE 822105 A IE822105 A IE 822105A IE 210582 A IE210582 A IE 210582A IE 822105 L IE822105 L IE 822105L
Authority
IE
Ireland
Prior art keywords
hydrogen
image
methyl
represents hydrogen
alkyl
Prior art date
Application number
IE822105A
Other versions
IE53615B1 (en
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of IE822105L publication Critical patent/IE822105L/en
Publication of IE53615B1 publication Critical patent/IE53615B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Feed For Specific Animals (AREA)
  • Fodder In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compounds of the formula <IMAGE> (A represents a single bond, -CH2-CH2-or <IMAGE> R4 represents hydrogen or alkyl, and R5 represents hydrogen or alkyl or, when R4 represents hydrogen, phenyl; R1 represents hydroxy, acyloxy, chlorine or hydrogen; R2 represents hydrogen, methyl or ethyl; R3 represents <IMAGE> m represents 2, 3 or 4, n represents 1,2, or 3, R6-8 represent hydrogen or methyl, R9 represents hydrogen, Ar, OAr, or -NH-CO-Ar <IMAGE> R10, R11, R12 are hydrogen, hydroxy, methyl, methoxy, halogen, -CONH2 or NH-R13, R13 is hydrogen, acyl or alkylsulfonyl, or any two of R10, R11, and R12 represent methylenedioxy), their acid addition salts, and corresponding compounds in which the CHOH group is replaced by CO (phenolic groups may be protected) are suitable for treating asthma, bronchitis, hay fever, cardiovascular disorders, for relaxation of the muscles of the uterus, and for improving flesh production and fodder utilisation in animals. [EP0073505A1]
IE2105/82A 1981-09-01 1982-08-31 Benzo heterocycles IE53615B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813134590 DE3134590A1 (en) 1981-09-01 1981-09-01 NEW BENZO HETEROCYCLES

Publications (2)

Publication Number Publication Date
IE822105L true IE822105L (en) 1983-03-01
IE53615B1 IE53615B1 (en) 1988-12-21

Family

ID=6140603

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2105/82A IE53615B1 (en) 1981-09-01 1982-08-31 Benzo heterocycles

Country Status (25)

Country Link
EP (1) EP0073505B1 (en)
JP (1) JPS5852278A (en)
KR (1) KR890000380B1 (en)
AR (2) AR231976A1 (en)
AT (1) ATE16703T1 (en)
AU (1) AU553589B2 (en)
CA (1) CA1180012A (en)
CS (1) CS236679B2 (en)
DD (1) DD204477A5 (en)
DE (2) DE3134590A1 (en)
DK (1) DK158664C (en)
ES (3) ES8308318A1 (en)
FI (1) FI78475C (en)
GB (1) GB2106105B (en)
GR (1) GR77275B (en)
HU (1) HU186112B (en)
IE (1) IE53615B1 (en)
IL (1) IL66683A0 (en)
NO (1) NO157738C (en)
NZ (1) NZ201777A (en)
PL (1) PL139375B1 (en)
PT (1) PT75478A (en)
SU (1) SU1149876A3 (en)
YU (1) YU42794B (en)
ZA (1) ZA826349B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554284A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones
DE3743265A1 (en) * 1987-12-19 1989-06-29 Boehringer Ingelheim Kg NEW AMMONIUM COMPOUNDS, THEIR MANUFACTURE AND USE
TW372967B (en) * 1994-12-27 1999-11-01 Kanebo Ltd 1,4 benzoxazine derivative, pharmaceutical composition containing the same and use thereof
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DE10253282A1 (en) 2002-11-15 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Treatment of chronic obstructive pulmonary disease, using new or known N-substituted 2-amino-1-(benz-(1,4)-oxazin-3-on-8-yl)-ethanol derivative beta-mimetic agents, suitable for once-daily administration
PE20040950A1 (en) 2003-02-14 2005-01-01 Theravance Inc BIPHENYL DERIVATIVES AS AGONISTS OF ß2-ADRENERGIC RECEPTORS AND AS ANTAGONISTS OF MUSCARINAL RECEPTORS
BRPI0409198A (en) * 2003-04-04 2006-05-02 Novartis Ag quinolin-2-one derivatives for the treatment of airway diseases
GB0307856D0 (en) * 2003-04-04 2003-05-14 Novartis Ag Organic compounds
EP1789394A1 (en) * 2004-05-13 2007-05-30 Boehringer Ingelheim International Gmbh Hydroxy-substituted benzo-condensed heterocycles for use as beta agonists in the treatment of respiratory diseases
US7307076B2 (en) 2004-05-13 2007-12-11 Boehringer Ingelheim International Gmbh Beta agonists for the treatment of respiratory diseases
DE102004024454A1 (en) * 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel enantiomerically pure beta agonists, process for their preparation and their use as pharmaceuticals
DE102004024452A1 (en) * 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosol formulation for the inhalation of beta agonists
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024451A1 (en) * 2004-05-14 2005-12-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder formulations for inhalation containing enantiomerically pure beta agonists
US7745621B2 (en) 2004-05-14 2010-06-29 Boehringer Ingelheim International Gmbh Long acting bronchodilators for the treatment of respiratory diseases
DE102004024453A1 (en) * 2004-05-14 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg New long-acting bronchodilators for the treatment of respiratory diseases
JP5270343B2 (en) * 2005-08-15 2013-08-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Beta mimetic manufacturing method
TWI389692B (en) * 2005-10-10 2013-03-21 Boehringer Ingelheim Int Aerosol formulations for the inhalation of beta-agonists
GB0602778D0 (en) 2006-02-10 2006-03-22 Glaxo Group Ltd Novel compound
JP2010500319A (en) * 2006-08-07 2010-01-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Enantiomerically pure new beta agonists, methods for their preparation and their use as medicaments
UY30543A1 (en) * 2006-08-18 2008-03-31 Boehringer Ingelheim Int AEROSOL FORMULATION FOR INHALATION OF BETA- AGONISTS
TWI409071B (en) * 2007-01-25 2013-09-21 Boehringer Ingelheim Int Process for the manufacturing of beta mimentics

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2035749A1 (en) * 1969-02-06 1970-12-24 Bellon Labor Sa Roger
CA1041523A (en) * 1974-06-19 1978-10-31 Queen's University Preparation of 1-oxapenicillins and novel intermediates therefor

Also Published As

Publication number Publication date
ES515380A0 (en) 1983-08-16
PL139375B1 (en) 1987-01-31
IE53615B1 (en) 1988-12-21
FI822985L (en) 1983-03-02
NO157738B (en) 1988-02-01
GB2106105A (en) 1983-04-07
ES8308318A1 (en) 1983-08-16
KR890000380B1 (en) 1989-03-15
CS236679B2 (en) 1985-05-15
JPH035392B2 (en) 1991-01-25
SU1149876A3 (en) 1985-04-07
AR231976A1 (en) 1985-04-30
ATE16703T1 (en) 1985-12-15
DE3134590A1 (en) 1983-03-10
YU42794B (en) 1988-12-31
FI78475C (en) 1989-08-10
YU194982A (en) 1984-12-31
IL66683A0 (en) 1982-12-31
EP0073505A1 (en) 1983-03-09
CA1180012A (en) 1984-12-27
NO157738C (en) 1988-05-11
HU186112B (en) 1985-06-28
AU8787482A (en) 1983-03-10
JPS5852278A (en) 1983-03-28
FI78475B (en) 1989-04-28
DK389082A (en) 1983-03-02
NZ201777A (en) 1985-08-30
NO822932L (en) 1983-03-02
DE3267702D1 (en) 1986-01-09
DD204477A5 (en) 1983-11-30
ES521871A0 (en) 1984-06-16
GB2106105B (en) 1985-07-10
DK158664B (en) 1990-07-02
ZA826349B (en) 1984-04-25
GR77275B (en) 1984-09-11
ES8402279A1 (en) 1984-01-16
ES521870A0 (en) 1984-01-16
EP0073505B1 (en) 1985-11-27
FI822985A0 (en) 1982-08-30
AU553589B2 (en) 1986-07-24
KR840001560A (en) 1984-05-07
AR231977A1 (en) 1985-04-30
PT75478A (en) 1982-09-01
ES8405778A1 (en) 1984-06-16
PL238077A1 (en) 1984-04-09
DK158664C (en) 1991-01-14

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Legal Events

Date Code Title Description
MM4A Patent lapsed