KR950700323A - 엔케팔리나제 및 안지오텐신 전환 효소의 억제제로서 유용한 아미노아세틸머캅토아세틸아미드 유도체(Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE) - Google Patents

엔케팔리나제 및 안지오텐신 전환 효소의 억제제로서 유용한 아미노아세틸머캅토아세틸아미드 유도체(Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE)

Info

Publication number
KR950700323A
KR950700323A KR1019940702796A KR19940702796A KR950700323A KR 950700323 A KR950700323 A KR 950700323A KR 1019940702796 A KR1019940702796 A KR 1019940702796A KR 19940702796 A KR19940702796 A KR 19940702796A KR 950700323 A KR950700323 A KR 950700323A
Authority
KR
South Korea
Prior art keywords
enkephalinase
ace
inhibitors
aminoacetylmercaptoacetylamide
derivatives useful
Prior art date
Application number
KR1019940702796A
Other languages
English (en)
Other versions
KR100276029B1 (ko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of KR950700323A publication Critical patent/KR950700323A/ko
Application granted granted Critical
Publication of KR100276029B1 publication Critical patent/KR100276029B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1019940702796A 1992-02-14 1993-01-08 아미노아세틸 머캅토아세틸 아미드 유도체 및 이의 제조방법 KR100276029B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US83602892A 1992-02-14 1992-02-14
US07/836028 1992-02-14
US98567892A 1992-12-11 1992-12-11
US07/985678 1992-12-11
PCT/US1993/000153 WO1993016103A1 (en) 1992-02-14 1993-01-08 Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace

Publications (2)

Publication Number Publication Date
KR950700323A true KR950700323A (ko) 1995-01-16
KR100276029B1 KR100276029B1 (ko) 2000-12-15

Family

ID=27125838

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940702796A KR100276029B1 (ko) 1992-02-14 1993-01-08 아미노아세틸 머캅토아세틸 아미드 유도체 및 이의 제조방법

Country Status (18)

Country Link
US (3) US5424425A (ko)
EP (1) EP0625987B1 (ko)
JP (1) JP3460838B2 (ko)
KR (1) KR100276029B1 (ko)
AT (1) ATE164593T1 (ko)
AU (1) AU668707B2 (ko)
CA (1) CA2130116C (ko)
DE (1) DE69317764T2 (ko)
DK (1) DK0625987T3 (ko)
ES (1) ES2117123T3 (ko)
FI (1) FI106717B (ko)
HU (1) HU220596B1 (ko)
IL (1) IL104716A (ko)
MX (1) MX9300777A (ko)
NO (1) NO311524B1 (ko)
NZ (1) NZ246811A (ko)
TW (1) TW225534B (ko)
WO (1) WO1993016103A1 (ko)

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AU668707B2 (en) * 1992-02-14 1996-05-16 Merrell Pharmaceuticals Inc. Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
US5679671A (en) * 1993-06-11 1997-10-21 Eisai Co., Ltd. Amino acid derivative
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
PT750631E (pt) * 1994-02-14 2000-07-31 Merrell Pharma Inc Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace
HUT74584A (en) * 1994-02-14 1997-01-28 Merrell Pharma Inc Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
CA2183314C (en) * 1994-02-14 1999-08-31 Gary A. Flynn Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
DE69514912T2 (de) * 1994-03-24 2000-10-05 Merrell Pharmaceuticals Inc., Cincinnati Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten
US5616775A (en) * 1994-05-05 1997-04-01 Bristol-Myers Squibb Co. Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US6020331A (en) 1995-03-24 2000-02-01 Molecumetics, Ltd. β-sheet mimetics and use thereof as protease inhibitors
US6245764B1 (en) 1995-03-24 2001-06-12 Molecumetics Ltd. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6699869B1 (en) 1995-03-24 2004-03-02 Myriad Genetics Inc. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US6117896A (en) 1997-02-10 2000-09-12 Molecumetics Ltd. Methods for regulating transcription factors
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
KR20010040939A (ko) * 1998-02-12 2001-05-15 몰레큐메틱스 리미티드 β-시트 미메틱 및 이의 사용과 관련된 방법
ATE302012T1 (de) 1998-06-17 2005-09-15 Bristol Myers Squibb Co Vorbeugung des hirninfarkts durch kombinierte verabreichung von adp-rezeptor antiblutplättchen und antihypertensiven medikamenten
DK1150976T3 (da) * 1998-12-31 2003-06-02 Aventis Pharma Inc 3-(Thiosubstituerede amido)lactamer, der er nyttige som inhibitorer af matrixmetalloproteinase
US6486193B2 (en) 1998-12-31 2002-11-26 Aventis Pharmaceuticals Inc. 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases
WO2000040564A1 (en) * 1998-12-31 2000-07-13 Aventis Pharmaceuticals Inc. N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
CN1642550A (zh) 2002-02-14 2005-07-20 美瑞德生物工程公司 β－折叠模拟物和组合物及其有关方法
DE10229180A1 (de) * 2002-06-28 2004-01-29 Aventis Pharma Deutschland Gmbh Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen

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Also Published As

Publication number Publication date
AU3439193A (en) 1993-09-03
HU9402355D0 (en) 1994-10-28
CA2130116C (en) 1998-04-07
FI943728A (fi) 1994-08-12
DK0625987T3 (da) 1999-01-11
AU668707B2 (en) 1996-05-16
US5488048A (en) 1996-01-30
DE69317764D1 (de) 1998-05-07
HUT71105A (en) 1995-11-28
ATE164593T1 (de) 1998-04-15
HU220596B1 (hu) 2002-03-28
JPH07503955A (ja) 1995-04-27
IL104716A0 (en) 1993-06-10
FI106717B (fi) 2001-03-30
EP0625987A1 (en) 1994-11-30
MX9300777A (es) 1993-08-01
NZ246811A (en) 1996-02-27
TW225534B (ko) 1994-06-21
DE69317764T2 (de) 1998-07-30
KR100276029B1 (ko) 2000-12-15
FI943728A0 (fi) 1994-08-12
WO1993016103A1 (en) 1993-08-19
NO942994D0 (no) 1994-08-12
US5529995A (en) 1996-06-25
JP3460838B2 (ja) 2003-10-27
US5424425A (en) 1995-06-13
ES2117123T3 (es) 1998-08-01
NO311524B1 (no) 2001-12-03
CA2130116A1 (en) 1993-08-19
IL104716A (en) 1997-09-30
EP0625987B1 (en) 1998-04-01
NO942994L (no) 1994-10-13

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