DK348678A - 3-hydroxycrotonsyrederivater til anvendelse som mellemprodukter ved fremstillingen af antiobiotisk virksomme 3-cephemforbindelser - Google Patents

3-hydroxycrotonsyrederivater til anvendelse som mellemprodukter ved fremstillingen af antiobiotisk virksomme 3-cephemforbindelser

Info

Publication number
DK348678A
DK348678A DK348678A DK348678A DK348678A DK 348678 A DK348678 A DK 348678A DK 348678 A DK348678 A DK 348678A DK 348678 A DK348678 A DK 348678A DK 348678 A DK348678 A DK 348678A
Authority
DK
Denmark
Prior art keywords
antiobiotic
activities
preparation
acid derivatives
cephem compounds
Prior art date
Application number
DK348678A
Other languages
English (en)
Inventor
R B Woodward
H Bickel
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH269374A external-priority patent/CH601310A5/de
Priority claimed from CH776674A external-priority patent/CH610584A5/de
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK348678A publication Critical patent/DK348678A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/04—Sulfinic acids; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK348678A 1974-02-26 1978-08-07 3-hydroxycrotonsyrederivater til anvendelse som mellemprodukter ved fremstillingen af antiobiotisk virksomme 3-cephemforbindelser DK348678A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH269374A CH601310A5 (en) 1974-02-26 1974-02-26 7-Amino-3-hydroxy-2(or 3)-cephem-4-carboxylic acid derivs prepn
CH776674A CH610584A5 (en) 1974-02-26 1974-06-05 Process for the preparation of 2-(3-amino-2-oxo-4-sulphonylthio-1- azetidinyl)-3-methylenebutyric acid derivatives
CH1100074 1974-08-12

Publications (1)

Publication Number Publication Date
DK348678A true DK348678A (da) 1978-08-07

Family

ID=27173851

Family Applications (2)

Application Number Title Priority Date Filing Date
DK73475*#A DK73475A (da) 1974-02-26 1975-02-25
DK348678A DK348678A (da) 1974-02-26 1978-08-07 3-hydroxycrotonsyrederivater til anvendelse som mellemprodukter ved fremstillingen af antiobiotisk virksomme 3-cephemforbindelser

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK73475*#A DK73475A (da) 1974-02-26 1975-02-25

Country Status (21)

Country Link
JP (1) JPS625919B2 (da)
AR (1) AR208538A1 (da)
AT (2) AT337362B (da)
AU (1) AU498131B2 (da)
BE (1) BE825919A (da)
BG (1) BG26201A3 (da)
CA (2) CA1059988A (da)
DD (1) DD117074A5 (da)
DE (1) DE2506330A1 (da)
DK (2) DK73475A (da)
ES (2) ES435110A1 (da)
FI (1) FI66389C (da)
FR (1) FR2261761B1 (da)
GB (1) GB1503581A (da)
HU (1) HU175212B (da)
IE (1) IE40695B1 (da)
IL (1) IL46699A (da)
NL (1) NL7502292A (da)
NO (1) NO750625L (da)
NZ (1) NZ176623A (da)
SE (3) SE431652B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1044247B (it) * 1974-08-02 1980-03-20 Farmaceutici Italia Intermedi per la sintesi di derivati b lattamici e procedimento per la loro preparazone
CA1136132A (en) * 1975-02-17 1982-11-23 Teruji Tsuji Cyclization to form cephem ring and intermediates therefor
JPS5198265A (da) * 1975-02-17 1976-08-30
AT342197B (de) * 1975-02-20 1978-03-28 Ciba Geigy Ag Neues verfahren zur herstellung von 3-cephemverbindungen
US4029645A (en) * 1975-11-17 1977-06-14 E. R. Squibb & Sons, Inc. Mercury intermediates useful in the preparation of 2-alkoxy cephalosporins
JPH0639474B2 (ja) * 1983-03-04 1994-05-25 大塚化学株式会社 セファロスポリン化合物の製造法
JPS59228854A (ja) * 1983-06-08 1984-12-22 真井　康博 薬液収納兼即効注出器
JPS60126263A (ja) * 1983-12-12 1985-07-05 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPS60237061A (ja) * 1984-05-08 1985-11-25 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
GB2152497B (en) * 1983-11-28 1987-08-05 Otsuka Kagaku Kk Process for the preparation of azetidinone derivatives
JPS60115562A (ja) * 1983-11-28 1985-06-22 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPS61178961A (ja) * 1985-02-01 1986-08-11 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren
JP3195959B2 (ja) * 1991-03-13 2001-08-06 大塚化学株式会社 ３−ヒドロキシセフェム誘導体の製造法
WO2004039813A1 (en) * 2002-11-01 2004-05-13 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of chloro methyl cephem derivatives
PL2794628T3 (pl) 2011-12-20 2017-09-29 Riboscience Llc 4'-azydo-3'-fluoro podstawione pochodne nukleozydów jako inhibitory replikacji RNA HCV
AU2012357940B2 (en) 2011-12-20 2017-02-16 Riboscience Llc 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
MA38678A1 (fr) 2013-05-16 2017-07-31 Riboscience Llc Dérivés nucléosidiques 4'-azido, 3'désoxy-3'-fluoro substitués
MA46490A1 (fr) 2013-05-16 2021-04-30 Riboscience Llc Dérivés de nucléosides 4'- fluoro-2' - méthyle substitués
US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
TWI860279B (zh) 2017-09-21 2024-11-01 美商里伯賽恩斯有限責任公司 作為hcv rna複製抑制劑之經4'-氟-2'-甲基取代之核苷衍生物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2230372A1 (de) * 1972-06-21 1973-01-11 Fujisawa Pharmaceutical Co Verfahren zur herstellung von oxidierten penam-derivaten
AR206201A1 (es) * 1972-06-29 1976-07-07 Ciba Geigy Ag Procedimiento para la obtencion de compuestos de acido 7beta-amino-3-cefem-3-01-4-carboxilico0-substituidos
SE428022B (sv) * 1972-06-29 1983-05-30 Ciba Geigy Ag 7beta-amino-cefam-3-on-4-karboxylsyraforeningar till anvendning for framstellning av cefalosporinderivat

Also Published As

Publication number Publication date
HU175212B (hu) 1980-06-28
FI66389B (fi) 1984-06-29
DK73475A (da) 1975-10-20
BE825919A (fr) 1975-08-25
FR2261761B1 (da) 1978-08-18
NL7502292A (nl) 1975-08-28
AT350068B (de) 1979-05-10
SE7807811L (sv) 1978-07-13
FI750503A (da) 1975-08-27
FR2261761A1 (da) 1975-09-19
NZ176623A (en) 1978-04-03
IE40695B1 (en) 1979-08-01
CA1059988A (en) 1979-08-07
CA1080713A (en) 1980-07-01
AU498131B2 (en) 1979-02-15
DE2506330A1 (de) 1975-09-04
JPS50129590A (da) 1975-10-13
GB1503581A (en) 1978-03-15
AT337362B (de) 1977-06-27
DD117074A5 (da) 1975-12-20
IL46699A (en) 1977-11-30
IL46699A0 (en) 1975-04-25
BG26201A3 (bg) 1979-02-15
AU7849875A (en) 1976-08-26
IE40695L (en) 1975-08-26
SE438855B (sv) 1985-05-13
SE7807810L (sv) 1978-07-13
SE438854B (sv) 1985-05-13
SE431652B (sv) 1984-02-20
FI66389C (fi) 1984-10-10
ES435110A1 (es) 1977-03-16
ES452915A1 (es) 1977-11-01
SE7501317L (da) 1975-08-27
JPS625919B2 (da) 1987-02-07
AR208538A1 (es) 1977-02-15
ATA28178A (de) 1978-10-15
NO750625L (da) 1975-08-27
ATA108275A (de) 1976-10-15

Similar Documents

Publication Publication Date Title
DK348678A (da) 3-hydroxycrotonsyrederivater til anvendelse som mellemprodukter ved fremstillingen af antiobiotisk virksomme 3-cephemforbindelser
DK155086C (da) Alfa-beskyttede oxyimino-beta-oxo-gamma-halogensmoersyrederivater til anvendelse som mellemprodukter ved fremstilling af cephemforbindelser
NO145884C (no) 7-methoxy-7-aminocefalosporansyreforbindelser for anvendelse som utgangsmaterialer ved fremstilling av 7-methoxy-7-acylaminocefalosporansyrederivater
DK289175A (da) Fremgangsmade til fremstilling af cyclohexylestere af vincaminsyrederivater
DK152756C (da) Imidazokinolinderivat til anvendelse som antireproduktionsmiddel
NO148188C (no) Benzofenon-derivater som mellomprodukter ved fremstilling av imidazo (1,5-alfa)(1,4)-benzodiazepiner
DK157080C (da) 7beta-amino-3-cephem-3-amino-4-carboxylsyrederivater til anvendelse som mellemprodukter ved fremstilling af 7beta-amino-3-cephem-3-ol-4-carboxylsyreforbindelser
DK211575A (da) 3-amino-phenyleddikesyrederivater fremgangsmade til deres fremstilling samt deres anvendelse som herbicider
DK157293C (da) Propionitril til anvendelse som mellemprodukt ved fremstilling af 6-aminosubstituerede-5-r3-2,4-diaminopyrimidin-3-oxider
DK423383A (da) Kemiske forbindelser til anvendelse som mellemprodukter ved fremstilling af 7-amino-3-cephem-4-carboxylsyrederivater
DK591975A (da) Fremgangsmade til fremstilling af phenyleddikesyrederivater
DK63990D0 (da) 7-aminocephalosporinderivater til anvendelse som mellemprodukt til fremstilling af sephalosporinderivater
DK446978A (da) Fremgangsmaade til fremstilling af cephalosporansyrederivater
DK453687A (da) Cephalosporinderivater til anvendelse som mellemprodukter ved fremstilling af antibakterielt virksomme 3-cephem-4-carboxylsyrederivater
DK187878A (da) N-phenyl-2-azacycloindol-forbindelser til anvendelse som mellemprodukter ved fremstilling af 2-substituerede n-phenyl-2-azacycloindol-forbindelser
DK446575A (da) Fremgangsmade til fremstilling af cephalosporansyrederivater
DK455675A (da) Fremgangsmade til fremstilling af preparater indeholdende diphenylethanolderivater
DK158787C (da) 3-pyrrolo-5-sulfamoylbenzoesyrederivater til anvendelse som mellemprodukter ved fremstilling af de tilsvarende pyrrolodinforbindelser
DK473875A (da) Fremgangsmade til fremstilling af clavulansyrederivater
DK152502C (da) Penamderivater til anvendelse som udgangsforbindelser ved fremstilling af terapeutisk aktive penamderivater
DK398880A (da) Anvendelse af clavudiener som mellemprodukt ved fremstillingen af clavulansyrederivater
DK200678A (da) Benzoxazolinonderivater til anvendelse som mellemprodukter ved fremstillingen af 5-formyl2-aminophenoler og fremgangsmaade til fremstilling af saadanne benzoxazolinonderivater
NO834608L (no) 2-(2-aminotiazol-4-yl)-2-oksyiminoeddiksyrederivater for bruk som mellomprodukter til fremstilling av terapeutisk virksomme forbindelser
DK460775A (da) Mellemprodukt til anvendelse ved fremstilling af 5-cyklohexyl-6-halogenindan-1-karboxylsyrederivater
DK456378A (da) Cephemderivater til anvendelse som mellemprodukter ved fremstilling af antibiotisk aktive cephemderivater

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment