ES364725A1 - Procedure for the preparation of new derivatives of paminoalquil-bencensulfonamida. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for the preparation of new p-aminoalkylbenzenesulfonamide derivatives of the general formula i ** (see formula) ** In which M is 2 or 3, R1 means an alkyl group with at most 12 carbon atoms, an alkenyl group with 3-5 carbon atoms, a cycloalkyl or cycloalkenyl group with at most 7 carbon atoms or a phenylalkyl group with 9 carbon atoms at most, R2 means hydrogen or an alkyl group with 2 carbon atoms at most, R3 means hydrogen, an alkyl or chloroalkyl group with at most 7 carbon atoms, an alkenyl group with not more than 5 carbon atoms, a cycloalkyl or cycloalkenyl group with not more than 8 carbon atoms, a phenyl group or a group phenylalkyl or phenylalkenyl with at most 10 carbon atoms, wherein the phenyl group present as r 3 or r 3 can be substituted one to three times by halogen up to atomic number 35, trifluromethyl groups, alkyl groups with 4 carbon atoms, carbon at most, hydroxyl groups, alkoxy or alkylthio with 2 carbon atoms at most, and R4 means hydrogen or the methyl group, And its addition salts with inorganic or organic acids, characterized in that an ester suitable for reaction of a compound of the general formula ii, ** (see formula) ** In which M, r2, r3 and r4 have the significance indicated under formula i, It is condensed and cyclized with an amine of the general formula iii, R1 - nh2 (III) In which R1 has the significance indicated under formula i, And the compound obtained is optionally converted with an inorganic or organic acid into an addition salt. (Machine-translation by Google Translate, not legally binding)