irreversible

And looking beyond its present woes, the industry faces tectonic shifts in demographics that suggest a potentially irreversible industry failure to market its products and build a new generation of customers.

Sir Keir has said Ukraine's path to Nato membership was "irreversible".

Sir Keir said Ukraine's path to Nato membership was "irreversible" and European nations "must increase our defence spending and take on a greater role" in the alliance.

Thompson, a former BBC and New York Times executive, called the moves a response “to profound and irreversible shifts in the way audiences in America consume news.”

Ms Bell says her life has been "flipped upside down" by taking the drugs that have some irreversible effects.