DE69128516D1 - Neue Mercaptoacetylamid-Derivate zur Verwendung als Enkephalinase- und ACE-Hemmer - Google Patents

Neue Mercaptoacetylamid-Derivate zur Verwendung als Enkephalinase- und ACE-Hemmer

Info

Publication number
DE69128516D1
DE69128516D1 DE69128516T DE69128516T DE69128516D1 DE 69128516 D1 DE69128516 D1 DE 69128516D1 DE 69128516 T DE69128516 T DE 69128516T DE 69128516 T DE69128516 T DE 69128516T DE 69128516 D1 DE69128516 D1 DE 69128516D1
Authority
DE
Germany
Prior art keywords
enkephalinase
new
ace inhibitors
mercaptoacetylamide derivatives
mercaptoacetylamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69128516T
Other languages
English (en)
Other versions
DE69128516T2 (de
Inventor
Gary A Flynn
Alan M Warshawsky
Shujaath Mehdi
Philippe Bey
Douglas W Beight
Eugene L Giroux
Timothy P Burkholder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69128516D1 publication Critical patent/DE69128516D1/de
Application granted granted Critical
Publication of DE69128516T2 publication Critical patent/DE69128516T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE69128516T 1990-10-18 1991-10-18 Neue Mercaptoacetylamid-Derivate zur Verwendung als Enkephalinase- und ACE-Hemmer Expired - Lifetime DE69128516T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60005290A 1990-10-18 1990-10-18
US73549691A 1991-07-25 1991-07-25

Publications (2)

Publication Number Publication Date
DE69128516D1 true DE69128516D1 (de) 1998-02-05
DE69128516T2 DE69128516T2 (de) 1998-07-23

Family

ID=27083513

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69128516T Expired - Lifetime DE69128516T2 (de) 1990-10-18 1991-10-18 Neue Mercaptoacetylamid-Derivate zur Verwendung als Enkephalinase- und ACE-Hemmer

Country Status (18)

Country Link
EP (1) EP0481522B1 (de)
JP (1) JP3181335B2 (de)
KR (1) KR100372491B1 (de)
CN (2) CN1036590C (de)
AT (1) ATE161536T1 (de)
AU (1) AU642535B2 (de)
CA (1) CA2053340C (de)
DE (1) DE69128516T2 (de)
DK (1) DK0481522T3 (de)
ES (1) ES2114870T3 (de)
FI (2) FI95255C (de)
GR (1) GR3026222T3 (de)
HU (1) HU210008B (de)
IE (1) IE913648A1 (de)
IL (1) IL99769A (de)
NO (1) NO180718C (de)
NZ (1) NZ240230A (de)
PT (1) PT99267B (de)

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US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
AU657793B2 (en) * 1991-09-27 1995-03-23 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2078759C (en) * 1991-09-27 2003-09-16 Alan M. Warshawsky Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
AU668707B2 (en) * 1992-02-14 1996-05-16 Merrell Pharmaceuticals Inc. Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
WO1993023403A1 (en) * 1992-05-15 1993-11-25 Merrell Dow Pharmaceuticals Inc. NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5298492A (en) * 1992-08-04 1994-03-29 Schering Corporation Diamino acid derivatives as antihypertensives
NZ254656A (en) * 1992-08-24 1995-12-21 Merrell Dow Pharma Tricyclic benzazepine derivatives; preparation and pharmaceutical compositions
US5208236A (en) * 1992-09-23 1993-05-04 Schering Corporation N-(acylaminomethyl)glutaryl amino acids and use
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
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US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
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DE69416873T2 (de) * 1994-02-14 1999-07-29 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
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US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
DE69514912T2 (de) * 1994-03-24 2000-10-05 Merrell Pharmaceuticals Inc., Cincinnati Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten
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US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
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US7009047B2 (en) 2002-03-19 2006-03-07 Sanofi-Aventis Deutschland Gmbh Ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenylpropanoate], processes for its preparation and its use
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Also Published As

Publication number Publication date
CA2053340A1 (en) 1992-04-19
FI914905A0 (fi) 1991-10-17
CN1058013C (zh) 2000-11-01
JPH04282382A (ja) 1992-10-07
ES2114870T3 (es) 1998-06-16
HU210008B (en) 1995-01-30
CN1166490A (zh) 1997-12-03
CN1061971A (zh) 1992-06-17
NO914092D0 (no) 1991-10-17
NO180718B (no) 1997-02-24
NZ240230A (en) 1993-01-27
NO180718C (no) 1997-06-04
ATE161536T1 (de) 1998-01-15
GR3026222T3 (en) 1998-05-29
AU642535B2 (en) 1993-10-21
FI943363A0 (fi) 1994-07-14
KR100372491B1 (ko) 2003-05-27
IE913648A1 (en) 1992-04-22
PT99267B (pt) 1999-04-30
NO914092L (no) 1992-04-21
FI943363A (fi) 1994-07-14
IL99769A (en) 1998-12-27
AU8581991A (en) 1992-04-30
JP3181335B2 (ja) 2001-07-03
HUT63419A (en) 1993-08-30
PT99267A (pt) 1992-08-31
CN1036590C (zh) 1997-12-03
DE69128516T2 (de) 1998-07-23
HU913282D0 (en) 1992-01-28
DK0481522T3 (da) 1998-03-09
EP0481522A1 (de) 1992-04-22
KR920008040A (ko) 1992-05-27
FI96691C (fi) 1996-08-12
CA2053340C (en) 2002-04-02
FI95255B (fi) 1995-09-29
IL99769A0 (en) 1992-08-18
FI914905A (fi) 1992-04-19
EP0481522B1 (de) 1997-12-29
FI95255C (fi) 1996-01-10
FI96691B (fi) 1996-04-30

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